Aging
Intervention in the effects of ageing
PetMoreTime uses interventions that act directly on the common effects of canine ageing, such as:
A 14-month program based on the science of ageing, reducing illness and extending your pet's life.
A 14-month program based on the science of ageing, reducing illness and extending your pet's life.
PetMoreTime
Research such as the Dog Aging Project and the Interventions Testing Program (USA) reveals that therapies with mTOR inhibitors, senolytics and immune modulation can prolong and improve pets' lives.
At PetMoreTime, we apply this cutting-edge science, under the leadership of Dr. Matt Kaeberlein (chief scientist of the Dog Aging Project), to help your dog live longer and better.
Our program combines examinations, supplements and pro-longevity therapies, aiming not only for health, but also for more years of happy life for your best friend.
Aging
PetMoreTime uses interventions that act directly on the common effects of canine ageing, such as:
Product
We have developed longevity protocols that offer the latest in science and technology to help your dog live longer and better.
Smart collar that monitors indicators of ageing
Personalized supplement and/or drug formulas
Consultations and examinations with specialized vets
Science
The 14-month Longevity Program costs R$ 14,280 and can be paid in up to 12 interest-free installments.
*A free chat with the PetMoreTime team is a prerequisite.
In this first month, you will tests and receive a collar PetMonitor. After that, you will face-to-face consultation and define the personalized treatment.
This month, you will receive the kit with the personalized formula.
In the third month, you will again examswith online or face-to-face feedback. You will then have a personalized treatment review based on the results.
In the seventh month, the examswith online or face-to-face feedback. Then you will personalized treatment review based on the results.
Receipt of formulas e monitoring treatment.
Closing consultation, analysis of results, personalized recommendations and next steps.
Science
Geroscience studies the biological mechanisms that drive ageing. Recent discoveries show that aging is governed by specific pathways and that today, for the first time, we can modulate these pathways with safe pharmacological interventions.
Personalized interventions
Every dog is unique, and so is its aging process. Our associate veterinarians are prepared to individualize the treatment by adjusting the program over the course of 14 months, guaranteeing optimal results.
Find out how our program can bring more years of happiness to you and your dog.
Published on January 1, 2025
Published on October 06, 2024
Veterinarians
At PetMoreTime, we value partnering with veterinarians who share our vision of improving the health and longevity of dogs.
With our program, you have access to real-time data from the smart collar and can closely monitor the health of the pets in your care.
Together, we can transform the way we care for dogs, promoting health and longevity.
Link
Aging is accompanied by gradual changes in most body systems. Research on the biology of aging focuses on understanding the cellular and molecular processes underlying these changes as well as those accompanying the onset of age-related diseases. As scientists learn more about these processes, experiments can be designed to better understand when and how pathological changes begin, providing important clues towards developing interventions to prevent or treat disease. A great deal has been learned about structural and functional changes that occur in different body systems, and progress is ongoing. Research has expanded our knowledge, too, of the biological factors associated with extended longevity in humans and animal models. This section of the NIA's narrative discusses some recent advances in the biology of aging, on cloning and transplantation and on lifespan itself. Selected future research directions are described as well, including continuing efforts to find biologic interventions to promote healthy aging, to understand the genetic basis of aging, and to explore the potential of adult stem cells and cell replacement for reducing disease and improving function.
Dogs act as companions who provide us with emotional and physical support. Their shorter lifespans compel us to learn about the challenges and gifts of caring for older individuals. Our companion dogs can be exemplars of healthy or unhealthy aging, and sentinels of environmental factors that might increase or decrease our own healthy lifespan. In recent years, the field of aging has emphasized not just lifespan, but healthspan-the period of healthy, active lifespan. This focus on healthy, active aging is reflected in the World Health Organization's current focus on healthy aging for the next decade and the 2016 Healthy Aging in Action initiative in the US. This paper explores the current research into aging in both people and companion dogs, and in particular, how the relationship between older adults and dogs impacts healthy, active aging for both parties. The human-dog relationship faces many challenges as dogs, and people, age. We discuss potential solutions to these challenges, including suggestions for ways to continue contact with dogs if dog ownership is no longer possible for an older person. Future research directions are outlined in order to encourage the building of a stronger evidence base for the role of dogs in the lives of older adults.
Across mammals, increased body size is positively associated with lifespan. However, within species, this relationship is inverted. This is well illustrated in dogs (Canis familiaris), where larger dogs exhibit accelerated life trajectories: growing faster and dying younger than smaller dogs. Similarly, some age-associated traits (e.g., growth rate and physiological pace of aging) exhibit accelerated trajectories in larger breeds. However, it is unknown whether cognitive performance also demonstrates an accelerated life course trajectory in larger dogs. Here, we measured cognitive development and aging in a cross-sectional study of over 4000 dogs from 66 breeds using nine memory and decision-making tasks performed by citizen scientists as part of the Dognition project. Specifically, we tested whether cognitive traits follow a compressed (accelerated) trajectory in larger dogs, or the same trajectory for all breeds, which would result in limited cognitive decline in larger breeds. We found that all breeds, regardless of size or lifespan, tended to follow the same quadratic trajectory of cognitive aging-with a period of cognitive development in early life and decline in later life. Taken together, our results suggest that cognitive performance follows similar age-related trajectories across dog breeds, despite remarkable variation in developmental rates and lifespan.
The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, receives comparable medical care, and has excellent veterinary medical data available.Past studies of dog lifespan have used academic, corporate or insurance data. While independent primary care data exist for the UK, none have as yet been published for the US. This study analyzed data from three independent primary care US veterinary hospitals and identified factors that influence lifespan and mortality in a cohort of n = 20,970 privately owned dogs using Kaplan-Meier survival estimators and Cox Proportional Hazards modelling, including body size as a covariate.
Inbreeding poses a real or potential threat to nearly every species of conservation concern. Inbreeding leads to loss of diversity at the individual level, which can cause inbreeding depression, and at the population level, which can hinder ability to respond to a changing environment. In closed populations such as endangered species and ex situ breeding programs, some degree of inbreeding is inevitable. It is therefore vital to understand how different patterns of breeding and inbreeding can affect fitness in real animals. Domestic dogs provide an excellent model, showing dramatic variation in degree of inbreeding and in lifespan, an important aspect of fitness that is known to be impacted by inbreeding in other species. There is a strong negative correlation between body size and lifespan in dogs, but it is unknown whether the higher rate of aging in large dogs is due to body size per se or some other factor associated with large size. We used dense genome-wide SNP array data to calculate average inbreeding for over 100 dog breeds based on autozygous segment length and found that large breeds tend to have higher coefficients of inbreeding than small breeds. We then used data from the Veterinary medical Database and other published sources to estimate life expectancies for pure and mixed breed dogs. When controlling for size, variation in inbreeding was not associated with life expectancy across breeds. When comparing mixed versus purebred dogs, however, mixed breed dogs lived about 1.2 years longer on average than size-matched purebred dogs. Furthermore, individual pedigree coefficients of inbreeding and lifespans for over 9000 golden retrievers showed that inbreeding does negatively impact lifespan at the individual level. Registration data from the American Kennel Club suggest that the molecular inbreeding patterns observed in purebred dogs result from specific breeding practices and/or founder effects and not the current population size. Our results suggest that recent inbreeding, as reflected in variation within a breed, is more likely to affect fitness than historic inbreeding, as reflected in variation among breeds. Our results also indicate that occasional outcrosses, as in mixed breed dogs, can have a substantial positive effect on fitness.
Humans, as well as their closest ancestors, the higher African primates, exhibit female-biased survival and multiple sex differences in causes of death. However, the effects of sex on aging and longevity in an excellent model of human health, the companion dog, have not been well explored. Using two large independent databases on companion dog longevity and causes of death, we performed the most extensive analysis of sex differences in dog aging to date. Unlike the findings in humans, we observed only a small effect of sex on canine longevity. When broken down by neutering status, we discovered a small male advantage in survival among intact dogs but a clear female survival advantage among neutered dogs. Overall, the effect of neutering on life span was greater than the effect of sex. However, we found few sex differences in causes of death in either intact or neutered dogs. The results of this study suggest limited sex effects on either longevity or causes of death in the companion dog. Our analysis suggests that the majority of apparent sex differences in the wider canine populations may be due to the effects of neutering.
To become a PetMoreTime licensed veterinarian, you must complete the longevity course offered by the company, be approved by the scientific committee and regularly participate in case discussions and updates. This process ensures that professionals are trained to apply the protocols safely and effectively, always based on the latest scientific findings.
The "Science" section of the PetMoreTime website provides details on the scientific foundations of the protocols developed.
The PetMoreTime protocol is a complete canine longevity program that includes:
The drugs and nutraceuticals are sent monthly. The doses and products used are reviewed every month to adapt to the pet and the moment of life it is in. This is because, just as no two barks are the same, each dog has unique needs that can change over time. The protocol is adjusted according to the veterinary assessment and the data collected by the smart collar, ensuring that the treatment is always the most appropriate for the animal's well-being.
What drives us? Health and Safety Always First
Total priority for your dog's well-being and safety, based on responsible science.
Innovation with purpose
Advanced science and technology come together to prolong the life and health of your best friend.
Personalized care
Programs designed to meet your best friend's unique needs.